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Latest Mprize Winners
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Z Dave Sharp
On October 8, 2009 Dave Sharp, University of Texas, San Antonio was awarded the Special Mprize Lifespan Achievement. This special recognition was for the first pharmaceutical intervention to successfully extend the life of laboratory mice. The study, published in the journal Nature, showed that when aging mice were given the drug rapamycin, they lived longer than other mice. Read more about rapamycin in the news and the event. 
Andrzej Bartke
"...Dwarf mice...lack growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH), (and) live much longer than their normal siblings, and exhibit many symptoms of delayed aging." 
Steven Spindler
"Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition, is a robust method of decelerating aging and the development of age-related diseases. The effects of CR are conserved in nearly every species tested, perhaps including humans. CR delays the onset and reduces the incidence and severity of age-related diseases, including cancer." |
Competitor David SinclairMy work focuses on preventing and treating major diseases by manipulating genes that control how fast we age. Ignoring the conventional wisdom that the aging process is too complex to find drugs that could slow it, we are working to uncover single genes that could dramatically extend the lifespan of laboratory organisms such as yeast, worms, flies and mice. Calorie Restriction (CR) is currently the only treatment that is proven to prevent all diseases of aging including cancer, heart disease, osteoporosis, diabetes and neurodegeneration. Recent studies in our lab and others indicate that the health benefits of CR are mediated by the Sirtuins, a recently discovered family of seven enzymes that control functions including metabolism, cell survival, and organ degeneration. 
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