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Latest Mprize Winners
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Z Dave Sharp
On October 8, 2009 Dave Sharp, University of Texas, San Antonio was awarded the Special Mprize Lifespan Achievement. This special recognition was for the first pharmaceutical intervention to successfully extend the life of laboratory mice. The study, published in the journal Nature, showed that when aging mice were given the drug rapamycin, they lived longer than other mice. Read more about rapamycin in the news and the event. 
Andrzej Bartke
"...Dwarf mice...lack growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH), (and) live much longer than their normal siblings, and exhibit many symptoms of delayed aging." 
Steven Spindler
"Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition, is a robust method of decelerating aging and the development of age-related diseases. The effects of CR are conserved in nearly every species tested, perhaps including humans. CR delays the onset and reduces the incidence and severity of age-related diseases, including cancer." |
Competitor Jennifer LemonAccording to a recent study by Jennifer Lemon, key factors implicated in aging include reactive oxygen species, inflammatory processes, insulin resistance, and mitochondrial dysfunction. All are exaggerated in transgenic growth hormone mice (TGM), which display a syndrome resembling accelerated aging. We formulated a complex dietary supplement containing 31 ingredients known to ameliorate all of the above features. We previously showed that this supplement completely abolished the severe age-related cognitive decline expressed by untreated TGM, and went on to demonstrate that longevity of both TGM and normal mice is extended by this supplement. Treated TGM showed a 28% increase (p < .00008) in mean longevity. An 11% increase in mean longevity was also significant (p < .002093) for treated normal mice, compared to untreated normal mice. These data support the hypothesis that TGM are a model of accelerated aging, and demonstrate that complex dietary supplements may be effective in ameliorating aging or age-related pathologies where simpler formulations have generally failed. 
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